CSP - acetylcysteine to ameliorate acute renal injury in a rat ardiopulmonary bypass model

ethods: Male Sprague–Dawley rats were divided into four groups (each n 6): ham group, cardiopulmonary bypass group, and two N-acetylcysteine–treated ardiopulmonary bypass groups (bolus doses of 200 and 500 mg/kg in cardiopulonary bypass prime). Blood samples were collected at the beginning of cardioulmonary bypass, at the cessation of cardiopulmonary bypass, and at 2 and 12 ostoperative hours. The kidneys were harvested at 12 postoperative hours.